It's much like PNG vs JPEG. Like JPEG, the most common video codecs all use compression based on the discrete cosine transform (DCT). This makes them well suite

It's much like PNG vs JPEG. Like JPEG, the most common video codecs all use compression based on the discrete cosine transform (DCT). This makes them well suited for most video content which has a lot of continuous tones. APNG is better suited for simple animations with lots of flat shading, where video codecs would generate ugly artifacts. A classic example where APNG would be preferred is the ubiquitous throbber animation used by various applications to indicate that they are busy with some task.