Apropos the 2010 PNAS article "Comparing genomes to computer operating systems in terms of the topology and evolution of their regulatory control networks" Abs

Apropos the 2010 PNAS article "Comparing genomes to computer operating systems in terms of the topology and evolution of their regulatory control networks" Abstract: "The genome has often been called the operating system (OS) for a living organism. A computer OS is described by a regulatory control network termed the call graph, which is analogous to the transcriptional regulatory network in a cell. To apply our firsthand knowledge of the architecture of software systems to understand cellular design principles, we present a comparison between the transcriptional regulatory network of a well-studied bacterium (Escherichia coli) and the call graph of a canonical OS (Linux) in terms of topology and evolution. We show that both networks have a fundamentally hierarchical layout, but there is a key difference: The transcriptional regulatory network possesses a few global regulators at the top and many targets at the bottom; conversely, the call graph has many regulators controlling a small set of generic functions." dx.doi.org/10.1073/pnas.0914771107 https://pdfs.semanticscholar.org/1e5a/bf57c88ad060046c5b2adcc362fe908090a8.pdf https://pdfs.semanticscholar.org/1e5a/bf57c88ad060046c5b2adc...