Really depends on what you are doing. Most of my work is coding. The big screen is directly in front of me, about 3ft away. The MBP is up against it at a sli

Really depends on what you are doing. Most of my work is coding. The big screen is directly in front of me, about 3ft away. The MBP is up against it at a slight angle on the left. I use a separate wireless keyboard and mouse. Generally I have a browser open on the MBP's screen for viewing documentation or my work in progress. On the big screen I have three or four terminal windows open, tiled side-by-side, for editing, commands line, etc. I have a boomerang shaped desk which is deep enough to put the big screen that far away. Any closer and I'm panning my head too much and that gets bothersome after a while.