Personally speaking I was on hydromorphone (orally) for a shattered ankle, and just 72 hours of taking it (at 66% max dose) was enough. Dropping from 2 pills t

Personally speaking I was on hydromorphone (orally) for a shattered ankle, and just 72 hours of taking it (at 66% max dose) was enough. Dropping from 2 pills to 1 caused some withdrawal symptoms, and 1 to 0 definitely caused nausea and insomnia. The surgeon nodded when he heard about this and said yep, that's expected. It's addictive over that short a timespan.