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Here's the paper cited by the article ... http://science.sciencemag.org/content/355/6329/1040 http://science.sciencemag.org/content/355/6329/1040 Abstract: W

by _rpd 10y ago

Here's the paper cited by the article ... http://science.sciencemag.org/content/355/6329/1040 http://science.sciencemag.org/content/355/6329/1040 Abstract: We describe complete design of a synthetic eukaryotic genome, Sc2.0, a highly modified Saccharomyces cerevisiae genome reduced in size by nearly 8%, with 1.1 megabases of the synthetic genome deleted, inserted, or altered. Sc2.0 chromosome design was implemented with BioStudio, an open-source framework developed for eukaryotic genome design, which coordinates design modifications from nucleotide to genome scales and enforces version control to systematically track edits. To achieve complete Sc2.0 genome synthesis, individual synthetic chromosomes built by Sc2.0 Consortium teams around the world will be consolidated into a single strain by “endoreduplication intercross.” Chemically synthesized genomes like Sc2.0 are fully customizable and allow experimentalists to ask otherwise intractable questions about chromosome structure, function, and evolution with a bottom-up design strategy.

skosuri 10y ago
Actually, it's 7 papers co-published in Science simultaneously. The others are: Synthesis, debugging, and effects of synthetic chromosome consolidation: synVI and beyond: http://science.sciencemag.org/content/355/6329/eaaf4831 http://science.sciencemag.org/content/355/6329/eaaf4831 “Perfect” designer chromosome V and behavior of a ring derivative: http://science.sciencemag.org/content/355/6329/eaaf4704 http://science.sciencemag.org/content/355/6329/eaaf4704 Deep functional analysis of synII, a 770-kilobase synthetic yeast chromosome: http://science.sciencemag.org/content/355/6329/eaaf4791 http://science.sciencemag.org/content/355/6329/eaaf4791 Bug mapping and fitness testing of chemically synthesized chromosome X: http://science.sciencemag.org/content/355/6329/eaaf4706 http://science.sciencemag.org/content/355/6329/eaaf4706 Engineering the ribosomal DNA in a megabase synthetic chromosome: http://science.sciencemag.org/content/355/6329/eaaf3981 http://science.sciencemag.org/content/355/6329/eaaf3981 3D organization of synthetic and scrambled chromosomes: http://science.sciencemag.org/content/355/6329/eaaf4597 http://science.sciencemag.org/content/355/6329/eaaf4597 Along with an introduction: http://science.sciencemag.org/content/355/6329/1038 http://science.sciencemag.org/content/355/6329/1038 and perspective: http://science.sciencemag.org/content/355/6329/1024 http://science.sciencemag.org/content/355/6329/1024
- sytelus 10y ago
  Are there any good resources to start in this field for non-biology majors? It seems they have now full end-to-end simulation so one can program yeast and even test it out at some extent with nothing but just a computer.
  - skosuri 10y ago
    They don't have that at all. This was a Herculean effort over 5 years with very few actual changes to the natural genome. I don't mean to make it seem not impressive (it is ambitious and impressive); it's that we are so far away from an end to end simulation of anything even orders of magnitude simpler than yeast.
  - 88e282102ae2e5b 10y ago
    Honestly, an introductory biology textbook is your best bet. But other response is correct: we can't even simulate a single protein well, much less an entire organism.

by _rpd 10y ago

skosuri 10y ago

Actually, it's 7 papers co-published in Science simultaneously. The others are: Synthesis, debugging, and effects of synthetic chromosome consolidation: synVI and beyond: http://science.sciencemag.org/content/355/6329/eaaf4831 http://science.sciencemag.org/content/355/6329/eaaf4831 “Perfect” designer chromosome V and behavior of a ring derivative: http://science.sciencemag.org/content/355/6329/eaaf4704 http://science.sciencemag.org/content/355/6329/eaaf4704 Deep functional analysis of synII, a 770-kilobase synthetic yeast chromosome: http://science.sciencemag.org/content/355/6329/eaaf4791 http://science.sciencemag.org/content/355/6329/eaaf4791 Bug mapping and fitness testing of chemically synthesized chromosome X: http://science.sciencemag.org/content/355/6329/eaaf4706 http://science.sciencemag.org/content/355/6329/eaaf4706 Engineering the ribosomal DNA in a megabase synthetic chromosome: http://science.sciencemag.org/content/355/6329/eaaf3981 http://science.sciencemag.org/content/355/6329/eaaf3981 3D organization of synthetic and scrambled chromosomes: http://science.sciencemag.org/content/355/6329/eaaf4597 http://science.sciencemag.org/content/355/6329/eaaf4597 Along with an introduction: http://science.sciencemag.org/content/355/6329/1038 http://science.sciencemag.org/content/355/6329/1038 and perspective: http://science.sciencemag.org/content/355/6329/1024 http://science.sciencemag.org/content/355/6329/1024

sytelus 10y ago
Are there any good resources to start in this field for non-biology majors? It seems they have now full end-to-end simulation so one can program yeast and even test it out at some extent with nothing but just a computer.
- skosuri 10y ago
  They don't have that at all. This was a Herculean effort over 5 years with very few actual changes to the natural genome. I don't mean to make it seem not impressive (it is ambitious and impressive); it's that we are so far away from an end to end simulation of anything even orders of magnitude simpler than yeast.
- 88e282102ae2e5b 10y ago
  Honestly, an introductory biology textbook is your best bet. But other response is correct: we can't even simulate a single protein well, much less an entire organism.