Yep. As was in the news a couple of days ago, sickle cell disease can be effectively 'cured' by installing an updated Hemoglobin protein [1]. (Some) Breast ca

Yep. As was in the news a couple of days ago, sickle cell disease can be effectively 'cured' by installing an updated Hemoglobin protein [1]. (Some) Breast cancer associated genes have pretty well understood issues that can be effectively remedied with gene therapies [2]. And mutations in and around the oncogene P53 have pretty well understood effects - all the way through public policy with regards to HPV vaccination [3]. Adding single proteins and flipping single genetic bits in single cell types in single organs is not the kind of thing that generally causes cascade failures. There are always exceptions, but in general biology is pretty robust to such changes. In fact, those are exactly the kinds of changes that occur from generation to generation. And these are precisely the kinds of systems that have been under deep study for the past four or five decades. [1] https://serotiny.bio/notes/proteins/hbb/ https://serotiny.bio/notes/proteins/hbb/ [2] https://serotiny.bio/notes/proteins/brca1/ https://serotiny.bio/notes/proteins/brca1/ [3] https://serotiny.bio/notes/proteins/p53/ https://serotiny.bio/notes/proteins/p53/