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The article mentions electron microscopy for connectomics. Do you think electron microscopy or expansion microscopy is more likely to succeed at reconstructing
by georgewfraser 10y ago
The article mentions electron microscopy for connectomics. Do you think electron microscopy or expansion microscopy is more likely to succeed at reconstructing the wiring diagram of real brains?
- stochastician 10y agoExpansion microscopy is new and exciting, but also still in progress, and I think struggles to identify some of the traditional areas where you have really fine neuropil. I'm actually most excited about Tony Zador and George Church's DNA-barcode approaches. They will potentially give us different answers, though -- DNA barcodes will give us a graph and detailed information about synapse sites, but not a lot about morphology, for example.