Slows glaucoma: https://dx.doi.org/10.1038/srep33950 https://dx.doi.org/10.1038/srep33950 Effects in long-lived mice: https://doi.org/10.1016/j.exger.2013.06.0

Slows glaucoma: https://dx.doi.org/10.1038/srep33950 https://dx.doi.org/10.1038/srep33950 Effects in long-lived mice: https://doi.org/10.1016/j.exger.2013.06.009 https://doi.org/10.1016/j.exger.2013.06.009 Protective of the aging heart: https://doi.org/10.1016/j.freeradbiomed.2009.10.003 https://doi.org/10.1016/j.freeradbiomed.2009.10.003 Benefits without calorie reduction: https://dx.doi.org/10.1073/pnas.1035720100 https://dx.doi.org/10.1073/pnas.1035720100 In nematodes, looking at signaling: http://dx.doi.org/10.1038/nature07583 http://dx.doi.org/10.1038/nature07583 And so on. There is a lot more out there on this topic: https://www.ncbi.nlm.nih.gov/pubmed/?term=alternate+day+fasting https://www.ncbi.nlm.nih.gov/pubmed/?term=alternate+day+fast... Researchers still have a very long way to go in order to understand the calorie restriction and intermittent fasting responses completely. In order to do that one pretty much as to have a complete map of cellular biochemistry. Don't hold your breath waiting for that to happen; decades is a very reasonable expectation, I think, based on watching progress in understanding sirtuins over more than a decade, which is just one very thin slice of a very large problem. Practical rejuvenation based on repair of damage after the SENS vision (such as via clearing senescent cells) will be a going concern well before researchers can fully explain calorie restriction in the context of age-related changes and cause and effect in the operation of mammalian biochemistry.