3 ms·
No. Drug-breakdown processes have long been studied, whereas this is something new. Drugs like caffeine are removed by metabolic enzymes in multiple stages - e.
by pizza 10y ago
No. Drug-breakdown processes have long been studied, whereas this is something new. Drugs like caffeine are removed by metabolic enzymes in multiple stages - e.g. here is a flowchart of caffeine's metabolic pathway https://s3.pgkb.org/pathway/PA165884757.png?versionId=XtszC77mTsmQlNujJSxYCeTW_V2XnLNw https://s3.pgkb.org/pathway/PA165884757.png?versionId=XtszC7...
- semi-extrinsic 10y agoBut that's not how caffeine is removed from the brain - that entire flowchart says "liver cell". Is one to understand that as the liver cleans blood of caffeine, and this low-caffeine blood eventually goes up to the brain, caffeine diffuses somehow (across the blood/brain barrier) into the bloodstream and is then carried to the liver?
- pizza 10y agoEssentially, to my knowledge.. of relevance: https://en.wikipedia.org/wiki/Distribution_(pharmacology) https://en.wikipedia.org/wiki/Distribution_(pharmacology) https://en.wikipedia.org/wiki/Pharmacokinetics https://en.wikipedia.org/wiki/Pharmacokinetics https://en.wikipedia.org/wiki/ADME https://en.wikipedia.org/wiki/ADME https://en.wikipedia.org/wiki/Compartment_(pharmacokinetics) https://en.wikipedia.org/wiki/Compartment_(pharmacokinetics) https://en.wikipedia.org/wiki/Clearance_(pharmacology) https://en.wikipedia.org/wiki/Clearance_(pharmacology) https://en.wikipedia.org/wiki/Plasma_protein_binding https://en.wikipedia.org/wiki/Plasma_protein_binding