Sure. This is just a higher level overview of the brain, I'm sure there are experts who can dive deeper into this matter. The brain is an extremely delicate or

Sure. This is just a higher level overview of the brain, I'm sure there are experts who can dive deeper into this matter. The brain is an extremely delicate organ, or atleast that's what I would consider it. It relies on maintaining balance and uses negative feedback. In an effort to regulate brain activity, your brain will do things like down-regulation as an effort to bring your high activity brain (while on lsd) to a more normal level. I haven't looked into exactly what happens with LSD besides that it acts on serotonergic pathways, but sustained high activity can also lead to cell death.