1. Use a folio style case so you can cradle the spine on one palm or two hands instead of needing to clamp down with thumb on top and fingers below. The aluminu

1. Use a folio style case so you can cradle the spine on one palm or two hands instead of needing to clamp down with thumb on top and fingers below. The aluminum/glass casing is slippery, and maintaining a vise-like grip tires out your muscles more quickly. 2. Imagine you're holding a hardcover War and Peace or Lord of the Rings instead of a paperback novel. Read it propped against a desk or the covers. 3. I find my eyes feel less strained if I'm reading in a shaded but not dark room. Try adjusting the ambient light? Hope that helps some. I'm surprised how awkward it is to surf the web on the ipad, but for reading ebooks it's almost everthing I could have wished for.