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You might look at the mitochondrial work which recently focused on Corral-Debrinski's lab as the most likely prospect for getting the job done. A brief outline

You might look at the mitochondrial work which recently focused on Corral-Debrinski's lab as the most likely prospect for getting the job done. A brief outline is at the end of this page: http://www.sens.org/sens-research/research-themes/mitosens http://www.sens.org/sens-research/research-themes/mitosens and you can look at Corral-Debrinski's breakthrough here: http://www.ncbi.nlm.nih.gov/pubmed/18771762 http://www.ncbi.nlm.nih.gov/pubmed/18771762 Basically it's now shown possible to move a mitochondrial gene into the nucleus and then have the proteins produced pushed back to the mitochondria for use. When done for the 13 important mitochondrial genes whose mutation damages us, then this will make it possible completely remove their contribution to aging. There is good reason to think that this is a large contribution. Context: http://www.fightaging.org/archives/2006/10/how-age-damaged-mitochondria-cause-your-cells-to-damage-you.php http://www.fightaging.org/archives/2006/10/how-age-damaged-m... How much money: $1 billion over ten years to implement SENS fully in mice. Incremental amounts obtain incremental progress.

jules 16y ago
How much of that money has been donated already? i.e. how much more is needed? It's interesting stuff. It makes me wonder whether I should be studying biology :)
- reasonattlm 16y ago
  I don't know how much SENS Foundation has raised since it diverged from the Methuselah Foundation. For the period prior to that, you can look at the Methuselah Foundation records: http://www.mfoundation.org/?pn=mj_donations_funding http://www.mfoundation.org/?pn=mj_donations_funding http://www.mfoundation.org/?pn=donors http://www.mfoundation.org/?pn=donors These are just ("just") a few millions - though I'm sure the folk reading HN will appreciate how much work went into raising those funds for a visionary project. By any account, a grand success in putting forward a new idea and bringing on board people who think the same way. Like all grand successes, it's the first step on a much longer path. (You may or may not know that one of the largest donors is Peter Thiel). In essence, SENS is still looking for the big hit, the scale up to mid-7-figures. By donating modestly now you add your name to hundreds of others who have already stepped up to help make the ramp needed for that goal.
borisk 16y ago
In humans, mitochondria have at least 615 distinct genes. Interestingly how these guys decided only 13 of them are important.

jules 16y ago

How much of that money has been donated already? i.e. how much more is needed? It's interesting stuff. It makes me wonder whether I should be studying biology :)

reasonattlm 16y ago
I don't know how much SENS Foundation has raised since it diverged from the Methuselah Foundation. For the period prior to that, you can look at the Methuselah Foundation records: http://www.mfoundation.org/?pn=mj_donations_funding http://www.mfoundation.org/?pn=mj_donations_funding http://www.mfoundation.org/?pn=donors http://www.mfoundation.org/?pn=donors These are just ("just") a few millions - though I'm sure the folk reading HN will appreciate how much work went into raising those funds for a visionary project. By any account, a grand success in putting forward a new idea and bringing on board people who think the same way. Like all grand successes, it's the first step on a much longer path. (You may or may not know that one of the largest donors is Peter Thiel). In essence, SENS is still looking for the big hit, the scale up to mid-7-figures. By donating modestly now you add your name to hundreds of others who have already stepped up to help make the ramp needed for that goal.

borisk 16y ago

In humans, mitochondria have at least 615 distinct genes. Interestingly how these guys decided only 13 of them are important.