3 ms·

He's looking for cures to issues that are real problems. If you fix any of the problems, even partially, they show great promise for helping older people to be

by gte910h 16y ago

He's looking for cures to issues that are real problems. If you fix any of the problems, even partially, they show great promise for helping older people to be decrepit, even if they don't actually extend lifespan. His hope is curing these types of damage will cause humans to functionally stop aging, but curing these types of damage are useful in and of themselves: Cell loss, tissue atrophy Nuclear [epi]mutations Mutant mitochondria Death-resistant cells Tissue stiffening Extracellular aggregates (Cleaning crap out of our bodies that shouldn't be there and isn't in cells) Intracellular aggregates (Cleaning crap out of cells that shouldn't be there and is in cells)

JulianMorrison 16y ago
In fact, the SENS foundation is ignoring some of those - because medical research is already attacking them as problems in their own right.
- MikeCapone 16y ago
  Yep, SENS isn't duplicating already existing research. If you support them, you are supporting research that might not take place otherwise.
DrJohnty 16y ago
In some areas we are making rapid progress on some rather less but solutions are know to all 7 causes of aging as outlined below. 1. Cell death and atrophy: Treatable with exercise, stem cells, and chemicals which stimulate cell division. 2. Cancerous cells: Theoretically treatable with a type of gene therapy being developed, called Whole Body Interdiction of Lengthening of Telomeres (WILT). 3. Mutant mitochondria: Mutated DNA in the mitochondria causes a number of diseases. These can be prevented by moving the mitochondrial DNA into the cell nucleus, where the rest of the DNA resides. 4. Death Resistant Cells or Cell senescence (unwanted cells): Fat cells and other unwanted cruft can be removed surgically, or by stimulating the immune system to attack unwanted cells. 5. Tissue stiffening or Extracellular crosslinks (loss of elasticity): Certain proteins, such as those in cells making up the arteries, become too rigid over time because they bond to each other. These bonds can be broken with certain chemicals (some in clinical trials even today). 6 Extracellular aggregates or junk: “Plaque” which collects between cells can be eliminated by stimulating the immune system, and/or by using peptides called “beta-breakers.” 7. Intracellular aggregates or junk: Molecular garbage can be prevented from overwhelming certain cells by introducing enzymes which are known to be effective against such molecules. In my opinion aging is no different to any other disease and like all diseases aging is ultimately treatable given the requisite technology. We cannot afford to sit back and simply accept that because everyone in history has lived and died we must follow the same path. It is a mistake to view aging as a fact of life set in stone when science has progressed to the level where we have the ability to begin the search for a cure. We might not be there yet but we are within striking distance of adding 20 or 30 years to our life expectancy and as Aubrey himself points out increases in life expectancy will be incremental and there is not going to be a sudden magic pill which you take and live forever. The essence of the engineering approach advocated by Aubrey is to manage aging, what he proposes is not a cure but a case of repairing the damage that occurs as we age at various intervals and not to stop the process but to allow the aging process to continue and repair the damage as it arises in the same way you maintain a house or car. This engineering approach is a case of taking advantage of improvements in technology as they occur and not to attempt to cure aging in its entirety and it is in this area that people fail to grasp what Aubrey de Grey is seeking to achieve. I recommend the two books below as great reading and all will be revealed! Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime (Aubrey de Grey and Michael Rae) ISBN-10: 0312367066 ISBN-13: 978-0312367060 Transcend: Nine Steps to Living Well Forever (Ray Kurzweil and Terry Grossman MD) ISBN-10: 1605299561 I would also check out the following regarding Aubrey de Grey http://www.citywire.co.uk/personal/-/retirement/news-and-features/content.aspx?ID=399808&Page=3 http://www.citywire.co.uk/personal/-/retirement/news-and-fea... and also the following about Ray Kurzweil if this lot does not wet your appetite for joining the war on aging nothing will! http://www.youtube.com/watch%3Fv%3DtQitQH8Fu_8 http://www.youtube.com/watch%3Fv%3DtQitQH8Fu_8 http://www.youtube.com/watch?v=ntY01qoIdus http://www.youtube.com/watch?v=ntY01qoIdus

by gte910h 16y ago

JulianMorrison 16y ago

In fact, the SENS foundation is ignoring some of those - because medical research is already attacking them as problems in their own right.

MikeCapone 16y ago
Yep, SENS isn't duplicating already existing research. If you support them, you are supporting research that might not take place otherwise.

DrJohnty 16y ago

In some areas we are making rapid progress on some rather less but solutions are know to all 7 causes of aging as outlined below. 1. Cell death and atrophy: Treatable with exercise, stem cells, and chemicals which stimulate cell division. 2. Cancerous cells: Theoretically treatable with a type of gene therapy being developed, called Whole Body Interdiction of Lengthening of Telomeres (WILT). 3. Mutant mitochondria: Mutated DNA in the mitochondria causes a number of diseases. These can be prevented by moving the mitochondrial DNA into the cell nucleus, where the rest of the DNA resides. 4. Death Resistant Cells or Cell senescence (unwanted cells): Fat cells and other unwanted cruft can be removed surgically, or by stimulating the immune system to attack unwanted cells. 5. Tissue stiffening or Extracellular crosslinks (loss of elasticity): Certain proteins, such as those in cells making up the arteries, become too rigid over time because they bond to each other. These bonds can be broken with certain chemicals (some in clinical trials even today). 6 Extracellular aggregates or junk: “Plaque” which collects between cells can be eliminated by stimulating the immune system, and/or by using peptides called “beta-breakers.” 7. Intracellular aggregates or junk: Molecular garbage can be prevented from overwhelming certain cells by introducing enzymes which are known to be effective against such molecules. In my opinion aging is no different to any other disease and like all diseases aging is ultimately treatable given the requisite technology. We cannot afford to sit back and simply accept that because everyone in history has lived and died we must follow the same path. It is a mistake to view aging as a fact of life set in stone when science has progressed to the level where we have the ability to begin the search for a cure. We might not be there yet but we are within striking distance of adding 20 or 30 years to our life expectancy and as Aubrey himself points out increases in life expectancy will be incremental and there is not going to be a sudden magic pill which you take and live forever. The essence of the engineering approach advocated by Aubrey is to manage aging, what he proposes is not a cure but a case of repairing the damage that occurs as we age at various intervals and not to stop the process but to allow the aging process to continue and repair the damage as it arises in the same way you maintain a house or car. This engineering approach is a case of taking advantage of improvements in technology as they occur and not to attempt to cure aging in its entirety and it is in this area that people fail to grasp what Aubrey de Grey is seeking to achieve. I recommend the two books below as great reading and all will be revealed! Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime (Aubrey de Grey and Michael Rae) ISBN-10: 0312367066 ISBN-13: 978-0312367060 Transcend: Nine Steps to Living Well Forever (Ray Kurzweil and Terry Grossman MD) ISBN-10: 1605299561 I would also check out the following regarding Aubrey de Grey http://www.citywire.co.uk/personal/-/retirement/news-and-features/content.aspx?ID=399808&Page=3 http://www.citywire.co.uk/personal/-/retirement/news-and-fea... and also the following about Ray Kurzweil if this lot does not wet your appetite for joining the war on aging nothing will! http://www.youtube.com/watch%3Fv%3DtQitQH8Fu_8 http://www.youtube.com/watch%3Fv%3DtQitQH8Fu_8 http://www.youtube.com/watch?v=ntY01qoIdus http://www.youtube.com/watch?v=ntY01qoIdus