3 ms·
Gwern, was there anything unusually interesting about age of menarche for GWAS?
by jessriedel 10y ago
Gwern, was there anything unusually interesting about age of menarche for GWAS?
- gwern 10y agoOh yes. Age of menarche is boring on its own, but the BMI and cancer correlations are interesting from an r/k selection perspective, and the tissue enrichment is especially interesting - what's with that massive overrepresentation of nervous system...? Well, it makes more sense when you read this in conjunction with "Physical and neurobehavioral determinants of reproductive onset and success" https://www.gwern.net/docs/genetics/correlation/2016-day.pdf https://www.gwern.net/docs/genetics/correlation/2016-day.pdf , Day et al 2016a and "Shared genetic aetiology of puberty timing between sexes and with health-related outcomes" http://www.nature.com/articles/ncomms9842 http://www.nature.com/articles/ncomms9842 , Day et al 2015. These variants, directly or indirectly, seem to cause a whole slew of risky behavioral changes.