All of this is not really relevant for TypeScript, as it just transpiles to Javascript and ends up running on the used Javascript VM. Sure, sometimes you might

All of this is not really relevant for TypeScript, as it just transpiles to Javascript and ends up running on the used Javascript VM. Sure, sometimes you might be able to generate more efficient code by tailoring the emitted Javascript to the VM behaviour or using something like typed arrays for low level operations, but if the target language doesn't have support for certain things like type hinting, there is not much that could be gained.