3 ms·
Genomic analyses for age at menarche identify 389 GWAS hits
- jessriedel 10y agoGwern, was there anything unusually interesting about age of menarche for GWAS?
- gwern 10y agoOh yes. Age of menarche is boring on its own, but the BMI and cancer correlations are interesting from an r/k selection perspective, and the tissue enrichment is especially interesting - what's with that massive overrepresentation of nervous system...? Well, it makes more sense when you read this in conjunction with "Physical and neurobehavioral determinants of reproductive onset and success" https://www.gwern.net/docs/genetics/correlation/2016-day.pdf https://www.gwern.net/docs/genetics/correlation/2016-day.pdf , Day et al 2016a and "Shared genetic aetiology of puberty timing between sexes and with health-related outcomes" http://www.nature.com/articles/ncomms9842 http://www.nature.com/articles/ncomms9842 , Day et al 2015. These variants, directly or indirectly, seem to cause a whole slew of risky behavioral changes.
- a_bonobo 10y agoWow, these p-values are tiny! Fig 1 has heaps of SNPs at -log10 > 50, that's crazy. Could be an effect of their relatively strange decision to use a simple model for GWAS - they used a straightforward linear regression with a more stringent p-value cutoff (P<5*10^-8), which I guess explains these ridiculously tiny p-values. I wonder how the results would have looked like with a more complex model (like an mixed linear model as implemented in GAPIT) or with a different strategy to adjust for multiple testing (all of those methods in PLINK)
- kgc 10y agoI read the abstract but couldn't understand the conclusion other than that the results for male and female were opposite. Can anyone explain?