Lumo (https://github.com/anmonteiro/lumo https://github.com/anmonteiro/lumo) or Planck may fit your requirements, though they lack a C FFI. They're based off Cl

Lumo (https://github.com/anmonteiro/lumo https://github.com/anmonteiro/lumo) or Planck may fit your requirements, though they lack a C FFI. They're based off ClojureScript/Javascript, and startup way faster than the JVM Clojure. Could probably try the node-ffi library with Lumo. There's the abandoned ClojureC project (https://github.com/schani/clojurec https://github.com/schani/clojurec). There's also JVM-to-native compilers like gcj or ExcelsiorJet. But at the moment, it doesn't seem like there's an established way to do all that.