The method for reducing calories can have dramatic differences in results. One of the flaws with the above cited study from what I remember was that it simply

The method for reducing calories can have dramatic differences in results. One of the flaws with the above cited study from what I remember was that it simply reduced calories but they still ate several times a day. The methods that are more associated with the positive benefits involve fasting windows. The macronutrients will also make a difference. A diet high in carbs would be horrible to use with reduced calories. The CR diets that seem more successful are ketogenic in nature.