5 ms·

Better write up: http://arstechnica.com/science/news/2010/05/first-functional-synthetic-bacterial-genome-announced.ars http://arstechnica.com/science/news/2010/

by glymor 16y ago

Better write up: http://arstechnica.com/science/news/2010/05/first-functional-synthetic-bacterial-genome-announced.ars http://arstechnica.com/science/news/2010/05/first-functional...

rms 16y ago
Or http://www.sciencemag.org/cgi/content/full/328/5981/958 http://www.sciencemag.org/cgi/content/full/328/5981/958
- raimondious 16y ago
  My favorite part from that article: So that the assembled genome would be recognizable as synthetic, four of the ordered DNA sequences contained strings of bases that, in code, spell out an e-mail address, the names of many of the people involved in the project, and a few famous quotations.
  - Evgeny 16y ago
    I guess sooner or later the random mutations may make these string "corrupted".
    - Devilboy 16y ago
      I hope they included checkbits!
      - zackattack 16y ago
        it may be a misconception but i think that checkbits are a feature of organic dna?
        biotech 16y ago
        Yep! There is some error-checking built into dna-replication. The protein that does the replication is called DNA Polymerase. From its wikipedia article: Error correction is a property of some, but not all, DNA polymerases. This process corrects mistakes in newly-synthesized DNA. When an incorrect base pair is recognized, DNA polymerase reverses its direction by one base pair of DNA. The 3'-5' exonuclease activity of the enzyme allows the incorrect base pair to be excised (this activity is known as proofreading). Following base excision, the polymerase can re-insert the correct base and replication can continue.
raimondious 16y ago
This one is pretty informative too http://www.nytimes.com/2010/05/21/science/21cell.html http://www.nytimes.com/2010/05/21/science/21cell.html Another one from Venter's website: http://www.jcvi.org/cms/research/projects/first-self-replicating-synthetic-bacterial-cell/overview/ http://www.jcvi.org/cms/research/projects/first-self-replica... (on HN http://news.ycombinator.com/item?id=1364544 http://news.ycombinator.com/item?id=1364544)

by glymor 16y ago

Better write up: http://arstechnica.com/science/news/2010/05/first-functional-synthetic-bacterial-genome-announced.ars http://arstechnica.com/science/news/2010/05/first-functional...

rms 16y ago

Or http://www.sciencemag.org/cgi/content/full/328/5981/958 http://www.sciencemag.org/cgi/content/full/328/5981/958

raimondious 16y ago
My favorite part from that article: So that the assembled genome would be recognizable as synthetic, four of the ordered DNA sequences contained strings of bases that, in code, spell out an e-mail address, the names of many of the people involved in the project, and a few famous quotations.
- Evgeny 16y ago
  I guess sooner or later the random mutations may make these string "corrupted".
  - Devilboy 16y ago
    I hope they included checkbits!
    - zackattack 16y ago
      it may be a misconception but i think that checkbits are a feature of organic dna?
      - biotech 16y ago
        Yep! There is some error-checking built into dna-replication. The protein that does the replication is called DNA Polymerase. From its wikipedia article: Error correction is a property of some, but not all, DNA polymerases. This process corrects mistakes in newly-synthesized DNA. When an incorrect base pair is recognized, DNA polymerase reverses its direction by one base pair of DNA. The 3'-5' exonuclease activity of the enzyme allows the incorrect base pair to be excised (this activity is known as proofreading). Following base excision, the polymerase can re-insert the correct base and replication can continue.

raimondious 16y ago

This one is pretty informative too http://www.nytimes.com/2010/05/21/science/21cell.html http://www.nytimes.com/2010/05/21/science/21cell.html Another one from Venter's website: http://www.jcvi.org/cms/research/projects/first-self-replicating-synthetic-bacterial-cell/overview/ http://www.jcvi.org/cms/research/projects/first-self-replica... (on HN http://news.ycombinator.com/item?id=1364544 http://news.ycombinator.com/item?id=1364544)