SJS is triggered by paracetamol & Acetaminophen [1] & antibiotics, among other drugs. It appears that one needs a complex set of conditions, which can occur wit

SJS is triggered by paracetamol & Acetaminophen [1] & antibiotics, among other drugs. It appears that one needs a complex set of conditions, which can occur with many drugs (including Modnafil & commonly used pain relievers, etc.). Note that I am not endorsing (or challenging) the use of the drug to enhance cognition. I just want to understand what evidence there is suggesting a higher rate of incidence with modnafil as compared to sulpha drugs & analgesics. Literature survey in Pubmed reveals fairly few reports [e.g: 2], describing only a handful of cases. If the argument is: the risk of SJS is not worth the likely benefits in improved cognition, I understand. But I am not convinced if there is compelling evidence linking modnafil with SJS. [edit: reorganized paragraphs; deleted unsubstantiated reference to allergies] [1] https://www.ncbi.nlm.nih.gov/pubmed/24527413 https://www.ncbi.nlm.nih.gov/pubmed/24527413 [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386138/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386138/