I think that the issue is that there is a fundamental difference in the entire view of drugs between people in society, one that is so large that it is nearly i

I think that the issue is that there is a fundamental difference in the entire view of drugs between people in society, one that is so large that it is nearly impossible to see across. This is what he is referring to. We permit, encourage or even glorify countless destructive, risky, or dangerous forms of behavior, including various legal mind altering substances. Alcoholism is known to be a serious issue, but alcohol and the vast ways that it is treated in our culture is widely accepted and encouraged. We allow extreme sports, or even "traditional" sports like gymnastics, most of us drive every day in conditions that should be objectively terrifying, we allow recreational firearm activities in most countries, smoking is legal, etc. But when it comes to drug use we put this huge social stigma on somewhat arbitrary substances, we impose significant punishments, we potentially ruin people's lives in the legal system, and all of this is so ingrained in our culture that even considering alternative systems is so radical that it seems like a fantasy. It's bizarre that such normal behavior is so incredibly reviled, when almost all of the negative consequences of it are due to the culture and legal system surrounding it rather than any physiological facts.