I do that for most of my sites but there are many things that require pixel-level adjustments. If all I'm making is a blog with headers and p, span tags, nobody

I do that for most of my sites but there are many things that require pixel-level adjustments. If all I'm making is a blog with headers and p, span tags, nobody cares if things don't line up exactly the same on my browser vs. their browser. However, take a look at: http://bulletxt.zetabee.com/demo http://bulletxt.zetabee.com/demo - not everything that is created using HTML/JS is a basic page. If you're trying to make even slightly complex web-apps, one extra pixel width will move things into the next line. It's very easy to say "design for standards" or "design for fluid layouts" but when it comes to actually coding it up, it just doesn't work like that. My point wasn't that I don't know how to make things work. In the end, all my finished products work well. My point was that it's a pain to make everything work nicely across all the browsers and that inconsistency causes headaches.