9 ms·
Isn't Mendelian Randomization prone to pleiotropy? I've never understood how people can control for that without a complete understanding of the genome.
by rb2k_ 10y ago
Isn't Mendelian Randomization prone to pleiotropy?
I've never understood how people can control for that without a complete understanding of the genome.
- bhalperin 10y agoDo you know any good overviews of Mendelian randomization?
- rb2k_ 10y agoI'm afraid not, my knowledge is all 2nd hand (wife is scientist) :)
- carbocation 10y agoYes, MR is prone to biased estimates due to pleiotropy. Attempting to unbias the estimators is a relatively hot topic right now.