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Does that mean a person in nutritional ketosis could die... ? Background for others: Most people in keto are running on mostly fatty acids and some ketones (fo

Does that mean a person in nutritional ketosis could die... ? Background for others: Most people in keto are running on mostly fatty acids and some ketones (for the things that can't use fatty acids) and a small amount of glucose from gluconeogenesis for the obligate glucose tissues (retina, small percentage of brain, etc). If you take away the ability to use fatty acids then you have to run off ketones, which should work, but I don't know if the body can make enough (and maybe that is impacted too?). And if your body is using gluconeogenesis to make your essential glucose from protein, and that is inhibited, I would think those tissues would be in trouble (its called essential glucose for a reason).

gamblor956 10y ago
Probably not. The study covers this in more detail than any of the articles, but malnutrition was the second biggest factor in the deaths. In most cases of sickness (and nearly all cases of death), the lychee was the bulk of the food eaten by the child. The children were already somewhat hypoglycemic because they weren't eating much, and due to their diet weren't ketogenic (minimal fat or protein in their diet). When the hypoglycin blocked the oxidation of the minimal fatty acids and protein in these children, they eventually ran out of usable glucose, resulting in seizures. For someone who is merely ketogenic, the hypoglycin would block some but not all of the oxidation of fatty acids, and [edit] generally would not effect the liver production of glucose from glycogen. The amount of dietary fats/proteins in a ketogenic diet would overcome the effect of the hypoglycin, and someone on a normal non-ketogenic diet might not even feel any symptoms due to the body's heavier reliance on the liver-glucose pathway.
- voidlogic 10y ago
  Thanks for this great reply, that makes sense. Do you know if hypoglycin interferes with the synthesis of beta hydroxybutyrate?
OldSchoolJohnny 10y ago
Um...no or there would be a hell of a lot of dead people around. Nutritional ketosis is probably the most up and coming diet there is right now.
- voidlogic 10y ago
  You realize I am asking about the effects of someone in nutritional ketosis who is getting a lot of hypoglycin lychee right? Of course I am not saying there is anything wrong with nutritional ketosis itself.

gamblor956 10y ago

Probably not. The study covers this in more detail than any of the articles, but malnutrition was the second biggest factor in the deaths. In most cases of sickness (and nearly all cases of death), the lychee was the bulk of the food eaten by the child. The children were already somewhat hypoglycemic because they weren't eating much, and due to their diet weren't ketogenic (minimal fat or protein in their diet). When the hypoglycin blocked the oxidation of the minimal fatty acids and protein in these children, they eventually ran out of usable glucose, resulting in seizures. For someone who is merely ketogenic, the hypoglycin would block some but not all of the oxidation of fatty acids, and [edit] generally would not effect the liver production of glucose from glycogen. The amount of dietary fats/proteins in a ketogenic diet would overcome the effect of the hypoglycin, and someone on a normal non-ketogenic diet might not even feel any symptoms due to the body's heavier reliance on the liver-glucose pathway.

voidlogic 10y ago
Thanks for this great reply, that makes sense. Do you know if hypoglycin interferes with the synthesis of beta hydroxybutyrate?

OldSchoolJohnny 10y ago

Um...no or there would be a hell of a lot of dead people around. Nutritional ketosis is probably the most up and coming diet there is right now.

voidlogic 10y ago
You realize I am asking about the effects of someone in nutritional ketosis who is getting a lot of hypoglycin lychee right? Of course I am not saying there is anything wrong with nutritional ketosis itself.