Businesses hire people to solve a problem. (Big surprise.) Therefore, to answer the question effectively, you need to figure out what problems they need to ha

Businesses hire people to solve a problem. (Big surprise.) Therefore, to answer the question effectively, you need to figure out what problems they need to have solved[0]. Figuring this out includes the research on the company you've (hopefully) done before applying, reading and fully understanding the job description, and asking questions during the screening & interview loop along the lines of "What issues is your business trying to solve?", "What role(s) do you want the person that you hire to play?", "What pain points does your organization have?", etc. From there, the response should more or less write itself: "My experience/skills in X, Y, and Z are going to help you solve problems A, B, and C that you're having" or, for less senior applicants, "I'm very interested in learning more about the technologies/skills you need me to have to solve problems A, B, C and my past work in I, J, K shows that I can acquire those skills easily and will be effective in applying them to your problems." [0] This includes ones that they may not even know they needed to have solved.