4 ms·
It should be "the [..] receptor-antagonist ketanserin" (can't take a dose of a receptor). And the effect isn't complete if I understand it correctly. But higher
by shaki-dora 10y ago
It should be "the [..] receptor-antagonist ketanserin" (can't take a dose of a receptor). And the effect isn't complete if I understand it correctly. But higher doses or a more potent antagonist could block the psychedelic effects completely, yes.
I'm not quite sure if LSD has non-psychedelic effects that are mediated through other mechanisms (such as other serotonin receptors, or maybe the dopaminergic system). From what I seem to remember (from that neurology lecture, mind you (where I was high)), LSD has some cardiovascular effects – basically everything you may experience from a large dose of caffein: rapid heartbeat, sweating, nervousness.
- tachyonbeam 10y agoLSD has a very wide receptor binding profile, see Table 8 of this paper: http://www.maps.org/research-archive/w3pb/2008/2008_Passie_23067_1.pdf http://www.maps.org/research-archive/w3pb/2008/2008_Passie_2... It also does bind to dopamine receptors, which is why it's more stimulating than other psychedelics.