4 ms·

I can tell you with personal experience that this is not true. I have taken 30-40mg before bed, and there is a definite difference in my experience from taking

by zeroer 10y ago

I can tell you with personal experience that this is not true. I have taken 30-40mg before bed, and there is a definite difference in my experience from taking 1-5mg. The sleepiness I felt 30-45 minutes after dosing was the most extreme sleepiness I've ever experienced in my life, the dreams are mind-blowing, and I feel tired the next day far beyond what I feel after taking a smaller dose.

heimatau 10y ago
Thanks for your personal experience but I was talking about scientific studies [1]. - [1] - https://www.ncbi.nlm.nih.gov/pubmed/12076414 https://www.ncbi.nlm.nih.gov/pubmed/12076414 - [2] (a narrow google search that i'm sure i could find more) - https://www.google.com/#q=melatonin+dosage+site:.gov+OR+site:.edu https://www.google.com/#q=melatonin+dosage+site:.gov+OR+site...
- zeroer 10y ago
  I don't see anything in that study about excess melatonin being evacuated. The paper only talks about effectiveness as a sleep aid.
  - heimatau 10y ago
    Under the main results section "Daily doses of melatonin between 0.5 and 5mg are similarly effective, except that people fall asleep faster and sleep better after 5mg than 0.5mg. Doses above 5mg appear to be no more effective." [1, from parent comment] Upon further research with the link I provided. It seems that for older people dosage levels should be introduced small and then increased, this study talks about the effectiveness of 50mg in older patients [1] [1] - https://www.ncbi.nlm.nih.gov/pubmed/24802882 https://www.ncbi.nlm.nih.gov/pubmed/24802882
    - zeroer 10y ago
      I don't see anything in your comment about excess melatonin being evacuated.
a_t48 10y ago
Could it be a placebo effect? If you were to randomly take either 5 mg or 40 mg would you notice the difference?
- zeroer 10y ago
  I did not do a double-blinded experiment, so I suppose I can't conclusively rule out a placebo effect. All I can say is that the effect is extremely unsubtle. 40mg of melatonin is a lot. It was a bad time in my life when I chose to do that, and I have no intention to repeat the experiment.

by zeroer 10y ago

heimatau 10y ago

Thanks for your personal experience but I was talking about scientific studies [1]. - [1] - https://www.ncbi.nlm.nih.gov/pubmed/12076414 https://www.ncbi.nlm.nih.gov/pubmed/12076414 - [2] (a narrow google search that i'm sure i could find more) - https://www.google.com/#q=melatonin+dosage+site:.gov+OR+site:.edu https://www.google.com/#q=melatonin+dosage+site:.gov+OR+site...

zeroer 10y ago
I don't see anything in that study about excess melatonin being evacuated. The paper only talks about effectiveness as a sleep aid.
- heimatau 10y ago
  Under the main results section "Daily doses of melatonin between 0.5 and 5mg are similarly effective, except that people fall asleep faster and sleep better after 5mg than 0.5mg. Doses above 5mg appear to be no more effective." [1, from parent comment] Upon further research with the link I provided. It seems that for older people dosage levels should be introduced small and then increased, this study talks about the effectiveness of 50mg in older patients [1] [1] - https://www.ncbi.nlm.nih.gov/pubmed/24802882 https://www.ncbi.nlm.nih.gov/pubmed/24802882
  - zeroer 10y ago
    I don't see anything in your comment about excess melatonin being evacuated.

a_t48 10y ago

Could it be a placebo effect? If you were to randomly take either 5 mg or 40 mg would you notice the difference?

zeroer 10y ago
I did not do a double-blinded experiment, so I suppose I can't conclusively rule out a placebo effect. All I can say is that the effect is extremely unsubtle. 40mg of melatonin is a lot. It was a bad time in my life when I chose to do that, and I have no intention to repeat the experiment.