Isn't this just really the general puzzle of how neurotransmitters work in the first place? We know their effects, in the broadest strokes (e.g. dopamine == rew

Isn't this just really the general puzzle of how neurotransmitters work in the first place? We know their effects, in the broadest strokes (e.g. dopamine == reward), but we don't know precisely how they create those effects.