Thank you! I've been looking for something like this to ameliorate the toxic aspects of caffine, whilst maintaining its positive effects. On this topic, and re

Thank you! I've been looking for something like this to ameliorate the toxic aspects of caffine, whilst maintaining its positive effects. On this topic, and related to the OP is the following study from 2010: https://www.ncbi.nlm.nih.gov/pubmed/20614853 https://www.ncbi.nlm.nih.gov/pubmed/20614853 "RESULTS: Paraxanthine, caffeine, and modafinil significantly promoted wakefulness in both WT and narcoleptic TG mice and proportionally reduced NREM and REM sleep in both genotypes. ... However, the higher doses of caffeine and modafinil, but not paraxanthine, induced hypothermia and reduced locomotor activity, thereby confirming the lower toxicity of paraxanthine." I was wondering whether anybody here has experience with paraxanthine? According to Wikipedia https://en.wikipedia.org/wiki/Caffeine https://en.wikipedia.org/wiki/Caffeine "Caffeine is metabolized in the liver into three primary metabolites: paraxanthine (84%), theobromine (12%), and theophylline (4%)" I'd also be interested to know whether anybody had authoritative references to the LD50 toxicity in humans for caffine and its 3 metabolites ...?