5 ms·

Read a funny statement in a study the other day. The lethal dose of cannabis for dogs is 3g/kg. Don't know if it translates to humans but if the order of magn

Read a funny statement in a study the other day. The lethal dose of cannabis for dogs is 3g/kg. Don't know if it translates to humans but if the order of magnitude is about the same then it takes on the order of 300 grams ingested to kill a human.

woliveirajr 10y ago
I bet that ingested paper or plastic have a lower FD50 for animals and humans...
- taneq 10y ago
  Less than a gram of swarf or other miscellaneous small sharp metal bits will do you in, so yeah.
narag 10y ago
Are those 300 g of pure cannabinoids or 300 g of dried flowers?
- Beltiras 10y ago
  It was in the context of the dogs eating cannabis that their owners were careless about so I'm assuming dried and pruned buds.
  - squeaky-clean 10y ago
    [Citation Needed] Unheated Marijuana doesn't have psychoactive effects. And like another poster said, the effects don't work through digestion without it binding to a fat. So just eating plain buds, even if they've been decarbed won't do much of anything. Edit: Found a study [0] that references the 3g/kg figure. That LD50 is for pure THC, not pure cannabis. "Lethal toxicity is reportedly rare with the THC LD50 = 3000 mg/kg in dogs.[2, 13] Both dogs that died in this study likely ingested significantly lower doses than the LD50 of THC; however, it is also possible that these dogs were more sensitive to THC or THC butter contains additional compounds that can be fatal in dogs." [0] http://onlinelibrary.wiley.com/doi/10.1111/j.1476-4431.2012.00818.x/full http://onlinelibrary.wiley.com/doi/10.1111/j.1476-4431.2012....
chimeracoder 10y ago
It's true. Marijuana is actually one of the very few substances with no known LD50. Technically there is hypothesized to be one, but it is so high that it would be literally impossible to ingest that much (you'd suffocate from lack of oxygen first, and that's assuming you somehow weren't incapacitated from being so high that you were able to keep smoking. So medically, that's considered equivalent to "no lethal dose exists". http://www.mindthesciencegap.org/2013/03/25/how-safe-is-marijuana-a-toxicological-perspective/ http://www.mindthesciencegap.org/2013/03/25/how-safe-is-mari...
- Beltiras 10y ago
  If you eat it you can ingest the dosage confirmed to kill dogs.
  - chimeracoder 10y ago
    > If you eat it you can ingest the dosage confirmed to kill dogs You would almost certainly vomit long before you hit that threshold. If you also took an anticonvulsant and just straight-up downed raw plant material, I suppose it's possible... but at that point, we're stretching the meaning of "lethal dose".
  - NTripleOne 10y ago
    It starts to get really complicated once you involve edibles, though - you can't just straight up eat plant matter and have it take effect as if you'd eaten a brownie, even though the dosage would technically be much, much higher if you straight up ate a bud. I'm no scientist nor a baker so I don't know the details behind it, but as far as I know the THC needs something to bind to before it's digestible, usually a fat - probably why cannabutter is the most common way of getting it into edibles. And that doesn't even account for the CBD which I have zero idea about with regards to edibles.
    - GordonS 10y ago
      It's also that THC isn't very psychoactive until it's been decarboxylated. The process of heating it within a particular temperature does this (e.g smoking, vaping, baking)

woliveirajr 10y ago

I bet that ingested paper or plastic have a lower FD50 for animals and humans...

taneq 10y ago
Less than a gram of swarf or other miscellaneous small sharp metal bits will do you in, so yeah.

narag 10y ago

Are those 300 g of pure cannabinoids or 300 g of dried flowers?

Beltiras 10y ago
It was in the context of the dogs eating cannabis that their owners were careless about so I'm assuming dried and pruned buds.
- squeaky-clean 10y ago
  [Citation Needed] Unheated Marijuana doesn't have psychoactive effects. And like another poster said, the effects don't work through digestion without it binding to a fat. So just eating plain buds, even if they've been decarbed won't do much of anything. Edit: Found a study [0] that references the 3g/kg figure. That LD50 is for pure THC, not pure cannabis. "Lethal toxicity is reportedly rare with the THC LD50 = 3000 mg/kg in dogs.[2, 13] Both dogs that died in this study likely ingested significantly lower doses than the LD50 of THC; however, it is also possible that these dogs were more sensitive to THC or THC butter contains additional compounds that can be fatal in dogs." [0] http://onlinelibrary.wiley.com/doi/10.1111/j.1476-4431.2012.00818.x/full http://onlinelibrary.wiley.com/doi/10.1111/j.1476-4431.2012....

chimeracoder 10y ago

It's true. Marijuana is actually one of the very few substances with no known LD50. Technically there is hypothesized to be one, but it is so high that it would be literally impossible to ingest that much (you'd suffocate from lack of oxygen first, and that's assuming you somehow weren't incapacitated from being so high that you were able to keep smoking. So medically, that's considered equivalent to "no lethal dose exists". http://www.mindthesciencegap.org/2013/03/25/how-safe-is-marijuana-a-toxicological-perspective/ http://www.mindthesciencegap.org/2013/03/25/how-safe-is-mari...

Beltiras 10y ago
If you eat it you can ingest the dosage confirmed to kill dogs.
- chimeracoder 10y ago
  > If you eat it you can ingest the dosage confirmed to kill dogs You would almost certainly vomit long before you hit that threshold. If you also took an anticonvulsant and just straight-up downed raw plant material, I suppose it's possible... but at that point, we're stretching the meaning of "lethal dose".
- NTripleOne 10y ago
  It starts to get really complicated once you involve edibles, though - you can't just straight up eat plant matter and have it take effect as if you'd eaten a brownie, even though the dosage would technically be much, much higher if you straight up ate a bud. I'm no scientist nor a baker so I don't know the details behind it, but as far as I know the THC needs something to bind to before it's digestible, usually a fat - probably why cannabutter is the most common way of getting it into edibles. And that doesn't even account for the CBD which I have zero idea about with regards to edibles.
  - GordonS 10y ago
    It's also that THC isn't very psychoactive until it's been decarboxylated. The process of heating it within a particular temperature does this (e.g smoking, vaping, baking)