Can anyone with access to the paper give a few technical details? The abstract mentions "Chronic nicotine administration" does this mean the nicotine dosage is

Can anyone with access to the paper give a few technical details? The abstract mentions "Chronic nicotine administration" does this mean the nicotine dosage is high enough to not be a viable basis for treatment? The linked article claims that this could be a basis for new drug research, which sounds exciting, but how much do we already know about drugs that affect the nicotinic receptors?