I don't think we need more studies to draw some useful conclusions, and sadly those conclusions do not bode well for the sedentary lifestyle. We know a lot abo

I don't think we need more studies to draw some useful conclusions, and sadly those conclusions do not bode well for the sedentary lifestyle. We know a lot about how human bodies evolved, both during our time as a species and our precursor species. We can also observe hunter-gatherer groups still active today, which is far more indicative of what kind of activity level we are programmed to get. One recent study I read showed that a modern hunter-gatherer group got a little over 2h of moderate to intense physical activity per day, and this produced a negligible risk of any kind of cardiovascular disease while producing a similar lifespan similar to our own. Humans evolved in an environment of this level of physical activity and we require that to retain our physical capacity and stave off disease.