Does it really matter that much if one calorie is not exactly equal to one calorie? What seems immediately obvious is that sugar is less filling per calorie tha

Does it really matter that much if one calorie is not exactly equal to one calorie? What seems immediately obvious is that sugar is less filling per calorie than almost anything else, and thus if you eat sugary foods you'll end up eating more calories. The only way to prevent this is to count precisely with an app or something, which is obviously a big challenge for most people.