3 ms·

> we know that once surplus white adipose tissue is grown, there's no going back, a modified diet must be adapted for life or those buckets just start filling a

by everial 10y ago

> we know that once surplus white adipose tissue is grown, there's no going back, a modified diet must be adapted for life or those buckets just start filling again Mind providing more references/reliable pointers on this?

joecool1029 10y ago
Apologies, I can't find the precise paper covering what I mean. You will find that there's a suspicious lack of studies on formerly obese people. Paper to get you thinking on how WAT acts on signaling: http://www.cambridge.org.secure.sci-hub.bz/core/journals/proceedings-of-the-nutrition-society/article/div-classtitlephysiological-role-of-adipose-tissue-white-adipose-tissue-as-an-endocrine-and-secretory-organdiv/6F914782A23DBDEC3E582833F6A16717 http://www.cambridge.org.secure.sci-hub.bz/core/journals/pro... Paper on WAT quantity and its effects on metabolic syndrome. http://onlinelibrary.wiley.com/doi/10.1111/eci.12519/pdf http://onlinelibrary.wiley.com/doi/10.1111/eci.12519/pdf . Where this one gets me thinking is that for some people, growing WAT may actually be an adaptation to prevent metabolic disorder from a poor diet. What we know is WAT can hold about 4x its size in fat before it divides into more. What we don't really know for humans is whether long term weight loss allows us to lose some of these, or whether they just deflate.... some rat studies show there can be a reduction, but for humans it would require repeated biopsy......
- everial 10y ago
  Thanks for the paper links.
- HeavenBanned 10y ago
  > There are physiotypes that will simply resist obesity on the worst of diets. Apologies for misunderstanding, but are you saying here that some individuals are able to eat as much as, say, a 300 lb obese male, yet somehow weigh-in at a rather fit (for example) 160 lb due to _genetic composition_?

3 ms·

> we know that once surplus white adipose tissue is grown, there's no going back, a modified diet must be adapted for life or those buckets just start filling a

by everial 10y ago

joecool1029 10y ago
Apologies, I can't find the precise paper covering what I mean. You will find that there's a suspicious lack of studies on formerly obese people. Paper to get you thinking on how WAT acts on signaling: http://www.cambridge.org.secure.sci-hub.bz/core/journals/proceedings-of-the-nutrition-society/article/div-classtitlephysiological-role-of-adipose-tissue-white-adipose-tissue-as-an-endocrine-and-secretory-organdiv/6F914782A23DBDEC3E582833F6A16717 http://www.cambridge.org.secure.sci-hub.bz/core/journals/pro... Paper on WAT quantity and its effects on metabolic syndrome. http://onlinelibrary.wiley.com/doi/10.1111/eci.12519/pdf http://onlinelibrary.wiley.com/doi/10.1111/eci.12519/pdf . Where this one gets me thinking is that for some people, growing WAT may actually be an adaptation to prevent metabolic disorder from a poor diet. What we know is WAT can hold about 4x its size in fat before it divides into more. What we don't really know for humans is whether long term weight loss allows us to lose some of these, or whether they just deflate.... some rat studies show there can be a reduction, but for humans it would require repeated biopsy......
- everial 10y ago
  Thanks for the paper links.
- HeavenBanned 10y ago
  > There are physiotypes that will simply resist obesity on the worst of diets. Apologies for misunderstanding, but are you saying here that some individuals are able to eat as much as, say, a 300 lb obese male, yet somehow weigh-in at a rather fit (for example) 160 lb due to _genetic composition_?