If you're including software no question the "holy grail" is https://en.wikipedia.org/wiki/Artificial_general_intelligence https://en.wikipedia.org/wiki/Artific

If you're including software no question the "holy grail" is https://en.wikipedia.org/wiki/Artificial_general_intelligence https://en.wikipedia.org/wiki/Artificial_general_intelligenc.... However it sounds more like you're asking what hardware innovations will enable fundamental performance improvements, or milestones that mark a large change in how things are engineered.