The paper you linked to doesn't really show that "chronic stress causes depression", though. The key sentence in the abstract, I think, is this: Here we p

The paper you linked to doesn't really show that "chronic stress causes depression", though. The key sentence in the abstract, I think, is this: Here we provide an overview of the evidence that chronic stress, which can precipitate or exacerbate depression, disrupts neuroplasticity, while antidepressant treatment produces opposing effects and can enhance neuroplasticity. The paper states that stress "contribute[s] to the development of major depression in susceptible individuals", as is well known. It also states that chronic stress correlates with features that are associated with major depressive disorder. Notice there not being any mention of a causal relationship here.