I can recommend: 1. Mindful meditation [free] -> Daily practice (30+ minutes) John Kabat-Zinn [0] masters the link between science and meditation and has publ

I can recommend: 1. Mindful meditation [free] -> Daily practice (30+ minutes) John Kabat-Zinn [0] masters the link between science and meditation and has published very valuable books (including guided/audio meditation exercises) [1]. There are a couple of scientific studies which prove effectiveness [2] [3]. 2. LSD [$5-10/dose + $25/multi-use test kit] -> One-time experience (every 6 months max.) Benefits (mid- and long-term) are similar to those of meditation. It however requires one to literally read/understand/know everything about the substance before applying it (minimum literature: "The psychedelic explorer's guide" by Fadiman). Also, order a test kit and test before you ingest. Certain "edge cases"/people should not try it. In addition, you may be able to access your spiritual dimension, which increases quality of life even further (it is less immediate with meditation). You may combine micro-dosing LSD with meditation for accessing the meditative state easier (it's quite a challenge for depressed people). [0] https://en.wikipedia.org/wiki/Jon_Kabat-Zinn https://en.wikipedia.org/wiki/Jon_Kabat-Zinn [1] https://thepiratebay.org/torrent/4180277/Mindful_Way_Through_Depression_-_Guided_Meditation_Practices https://thepiratebay.org/torrent/4180277/Mindful_Way_Through... [2] http://news.harvard.edu/gazette/story/2011/01/eight-weeks-to-a-better-brain http://news.harvard.edu/gazette/story/2011/01/eight-weeks-to... [3] http://www.vox.com/2015/8/27/9214697/meditation-brain-neuroscience http://www.vox.com/2015/8/27/9214697/meditation-brain-neuros...