Because we know genetic loci do not affect the phenotype in purely orthogonal ways (this is known as epistasis), there is a huge risk of having unforeseen secon

Because we know genetic loci do not affect the phenotype in purely orthogonal ways (this is known as epistasis), there is a huge risk of having unforeseen second order consequences. In state space even on simple models like NK model for low K, epistasis can have profound effects on fitness metrics and survivability as organisms attempt to hill climb.