> As a thought experiment ask yourself this: if there are no disadvantages then why hasn't the human brain evolved to operate that way normally without medicati

> As a thought experiment ask yourself this: if there are no disadvantages then why hasn't the human brain evolved to operate that way normally without medication? Biochemistry has nearly infinite degrees of freedom that have to be encoded by a small genetic code, evolution is far more likely to find a local maximum instead of a global one, sexual reproduction guarantees that genes are passed on in groups where one [mal]adaptation can drown out the consequences of all the others, and many drugs are only effective because they are some kind of chemical analog that effects a receptor or reaction that developed for an entirely different purpose (for example, cannabis is a psychoactive because of the endocannabinoid system, a set of neurotransmitter receptors involved in mood, memory, and appetite that likely evolved without exposure to the ancestors of cannabis). Evolution on Earth may have had billions of years but that is nowhere near enough to explore the entire solution space for survival in a constantly changing environment.