I worked in the trucking industry for about seven years, so I can answer some of these. Most trucks in the US are owned by individuals are very small companies

I worked in the trucking industry for about seven years, so I can answer some of these. Most trucks in the US are owned by individuals are very small companies. I'm not aware of any taxes specific to interstate trucking. If you have a licensed and insured truck in one state you're good to go anywhere in the US. There are some slightly different regulations on trailer length and such, but there is a consistent baseline across the US. There are toll roads but they're uncommon, especially in the middle of the country where most of the freight is moving. Those that do exist are fairly inexpensive and would be trivially easy to price in. Carriers are generally not responsible for the contents of their cargo. If they accept a big 'ole pallet marked "cocaine" they're gonna be in trouble, but they're not required to ensure that the cargo matches the manifest. LTL (less-than-truckload) cargo is generally delivered to your doorstep on a given day, not at a given hour. Trucks are commercial vehicles, so insurance is going to be much less of an issue there.