3 ms·

tl;dr; those prone to schizophrenia may increase psychosis risk if they are consumers of marijuana.

• DanBC 10y ago
  The article links to the study (this is great, and I wish more people did that). The study has a nice tl;dr https://www.cambridge.org/core/services/aop-cambridge-core/content/view/122D651C3670683DAEDDA33997417105/S0033291716003172a.pdf/div-class-title-assessing-causality-in-associations-between-cannabis-use-and-schizophrenia-risk-a-two-sample-mendelian-randomization-study-div.pdf https://www.cambridge.org/core/services/aop-cambridge-core/c... > Results. There was some evidence consistent with a causal effect of cannabis initiation on risk of schizophrenia [odds ratio (OR) 1.04 per doubling odds of cannabis initiation, 95% confidence interval (CI) 1.01 1.07, p = 0.019]. There was strong evidence consistent with a causal effect of schizophrenia risk on likelihood of cannabis initiation (OR 1.10 per doubling of the odds of schizophrenia, 95% CI 1.05–1.14, p = 2.64 × 10−5). Findings were as predicted for the negative control (height: OR 1.00, 95% CI 0.99–1.01, p = 0.90) but weaker than predicted for the positive control (years in education: OR 0.99, 95% CI 0.97–1.00, p = 0.066) analyses. > Conclusions. Our results provide some that cannabis initiation increases the risk of schizophrenia, although the size of the causal estimate is small. We find stronger evidence that schizophrenia risk predicts cannabis initiation, possibly as genetic instruments for schizophrenia are stronger than for cannabis initiation