3 ms·

>combination of endorphins The primary component of a runner's high is attributed to a category of neurotransmitters known as endocannabinoids. Endorphins beco

by ipnon 10y ago

>combination of endorphins The primary component of a runner's high is attributed to a category of neurotransmitters known as endocannabinoids. Endorphins become the primary component of a runner's high when the body becomes structurally damaged, like when marathon runners struggle to remain standing and lose the ability to concentrate (note the similarities to heroin consumption). The feelings of well-being and the Zen-like state that comes about from running a few miles is almost entirely due to endocannabinoids, similar to when someone has consumed cannabis.

is_this_valid 10y ago
> [endocannabinoids] - Endocannabinoid_system#Role_in_hippocampal_neurogenesis https://en.wikipedia.org/wiki/Endocannabinoid_system#Role_in_hippocampal_neurogenesis https://en.wikipedia.org/wiki/Endocannabinoid_system#Role_in... >> In the adult brain, the endocannabinoid system facilitates the neurogenesis of hippocampal granule cells.[37][38] In the subgranular zone of the dentate gyrus, multipotent neural progenitors (NP) give rise to daughter cells that, over the course of several weeks, mature into granule cells whose axons project to and synapse onto dendrites on the CA3 region.[39] NPs in the hippocampus have been shown to possess fatty acid amide hydrolase (FAAH) and express CB1 and utilize 2-AG.[38] Intriguingly, CB1 activation by endogenous or exogenous cannabinoids promote NP proliferation and differentiation; this activation is absent in CB1 knockouts and abolished in the presence of antagonist.[37][38] - "Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253627/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253627/ - https://en.wikipedia.org/wiki/Hippocampus https://en.wikipedia.org/wiki/Hippocampus - https://en.wikipedia.org/wiki/Neurogenesis https://en.wikipedia.org/wiki/Neurogenesis

by ipnon 10y ago

is_this_valid 10y ago

> [endocannabinoids] - Endocannabinoid_system#Role_in_hippocampal_neurogenesis https://en.wikipedia.org/wiki/Endocannabinoid_system#Role_in_hippocampal_neurogenesis https://en.wikipedia.org/wiki/Endocannabinoid_system#Role_in... >> In the adult brain, the endocannabinoid system facilitates the neurogenesis of hippocampal granule cells.[37][38] In the subgranular zone of the dentate gyrus, multipotent neural progenitors (NP) give rise to daughter cells that, over the course of several weeks, mature into granule cells whose axons project to and synapse onto dendrites on the CA3 region.[39] NPs in the hippocampus have been shown to possess fatty acid amide hydrolase (FAAH) and express CB1 and utilize 2-AG.[38] Intriguingly, CB1 activation by endogenous or exogenous cannabinoids promote NP proliferation and differentiation; this activation is absent in CB1 knockouts and abolished in the presence of antagonist.[37][38] - "Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253627/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253627/ - https://en.wikipedia.org/wiki/Hippocampus https://en.wikipedia.org/wiki/Hippocampus - https://en.wikipedia.org/wiki/Neurogenesis https://en.wikipedia.org/wiki/Neurogenesis