How clear is it that the isolation actually precedes the disease rather than potentially being a symptom? A disease process doesn't pop into existence when the

How clear is it that the isolation actually precedes the disease rather than potentially being a symptom? A disease process doesn't pop into existence when the condition is diagnosed, and diagnosis often doesn't occur before the condition leads to some kind of crisis. Many conditions' symptoms include depressed mood and fatigue, which tend to reduce social activity.