If the comment is still within the time it can be edited, you can, unless it has a response. In that case, if you want the comment effectively gone, you can edi

If the comment is still within the time it can be edited, you can, unless it has a response. In that case, if you want the comment effectively gone, you can edit the comment to remove the content. As a courtesy to the reader, you can leave a "[self-deleted]" or some such to indicate what happened.