You can use Guix as a standalone package manager on pretty much any GNU+Linux distribution. It only affects /gnu, /var/guix, and /etc/guix/acl. It won't touch

You can use Guix as a standalone package manager on pretty much any GNU+Linux distribution. It only affects /gnu, /var/guix, and /etc/guix/acl. It won't touch any global state (e.g. libraries in /usr, or binaries in /bin) and won't use any global state when building packages.