My wife has been on venlafaxine for years, and has been tappering off it for the past year. She has had horrible withdrawl symptoms from missing a single dose,

My wife has been on venlafaxine for years, and has been tappering off it for the past year. She has had horrible withdrawl symptoms from missing a single dose, like you describe. Each time the doses town (tapering), she has a rough few weeks. How long were you on it? Do you have any advice? Thanks.