So far the comments have strayed mightily from the locus. The article concerns molecular medicine. We are a computationally oriented group, and as such are bet

So far the comments have strayed mightily from the locus. The article concerns molecular medicine. We are a computationally oriented group, and as such are better served by combining our brain trust to define and use what technological tools may avail the molecular mechanics at issue. I've worked for a top-5 molecular modeling research center and can say from experience that there are a few things to do to rectify this dilemma. Before positing my solution(s), let's address what happens so the solutions make sense. The proteins malform and the resulting tertiary structure does not aggregate properly, thus producing physical interactions that disrupt the typical cellular processes. These malformations are caused by genetic mutations, or by heavy atomic elements that are either stochastically introduced into the cell or are the by-product of, say, working in a plutonium factory. The malformations are very common, and so over the aeons we have adapted a nice little helper molecule to do some repair work for us. These molecules are called pharmacological chaperones and are fucking amazing, pardon ma Francais... The gist of what they do reform the tertiary structure by aligning somewhat near the malformed protein and subsequently, almost inadvertently, it might seem to an untrained observer, polarize the molecule ever so slightly such that the tertiary structure reforms (there is a pun to be made here about social change, but I digress) and the unwanted behavior is no longer present. My thesis work is geared to designing algorithms that map molecular topography so we can better predict tertiary structure (itself an enormous undertaking, AWS, Azure, BlueMix, you listening?!) and then design (using some nifty techniques I've learned in my AI classes) the organic molecule that has the most empirically demonstrative capacity for altering the malformed protein to prevent any disease resulting from said malformation. That includes, but is not limited to, Prion diseases, many, if not most, cancers, and neuron centered degenerative diseases. It's kind of a big deal...to quote a certain broadcaster :p The reality is that we ARE fairly close to proving how to fix this, though Lord knows I could use a side gig to bouy me through the debts I have mounting, and I'm working on securing NHS, NSF and hopefully even some private dollars to scale my work into practical (meaning applicably utile, and not simply published) products that can solve the cancer crisis we currently endure. Long ass answer, but that's where the state of the art is on this topic, for which I am grateful to have this forum to discuss with whomever is on the other end of this server, and for the opportunity to pursue my research with the help of my mentors and senior scientists. For reasons begging belief I will not mention their names until we publish and hope that this brief description gives a little tinder to light a bit of a blaze under this scientifically, socially, and evolutionarily important topic. Cheers, y'all.