You can play with this map to see where the changes are biggest and smallest. Interestingly, the strip from Maryland to Georgia - which normally stands out in

You can play with this map to see where the changes are biggest and smallest. Interestingly, the strip from Maryland to Georgia - which normally stands out in US political maps, due to issues of slavery and race - stands out as being one big area where deaths due to drugs or substance abuse didn't increase much at all, annually, from a relatively low start.