Broad is part of the problem. It's very difficult to get qualified reviewers when you haven't narrowed the scope. One of the primary problems with PLOS ONE is t

Broad is part of the problem. It's very difficult to get qualified reviewers when you haven't narrowed the scope. One of the primary problems with PLOS ONE is that it exasperates problems already seen in other journals that cover too much. Why would you expect a specialist in awake single neuron experiments to be able to review and MRI study? Sure, there are some really good people out there, but for the most part, such reviews are going to be arbitrary.