Interested to hear how this is "precision oncology". Do the 5hmC patterns predict treatment response? (Spoiler: no, because this was retrospective; need a tria

Interested to hear how this is "precision oncology". Do the 5hmC patterns predict treatment response? (Spoiler: no, because this was retrospective; need a trial to validate) Do they provide information above and beyond IDH or co-1/19 status? (Spoiler: also no, partly because N=30 instead of over 1,000 in the TCGA LGG/GBM cohort) I would expect this from the PR organs of a major university or other donation-pandering body. I am saddened to see it from Collins, who knows better. The treatments that seem to work in glioblastoma center on dendritic cell vaccines or T-cell priming, at least at this point in time. Radiation is a temporary respite and only succeeds for focal (rather than diffuse) lesions in most cases; furthermore, "success" is relative (very few GBM cases are cured, even in younger patients). So while trials are afoot doing the brutally difficult work of evaluating actual candidates for cures, we're directed towards studies of marks that are almost certainly a proxy for metabolic activity. In bulk cells, natch. Way to go. :-(